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KMID : 1094720160210030463
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Biotechnology and Bioprocess Engineering
2016 Volume.21 No. 3 p.463 ~ p.476
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Synthesis and algicidal activity of new dichlorobenzylamine derivatives against harmful red tides
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Choi Du-Bok
Yu Sun-Jong
Baek Seung-Ho
Kang Yoon-Ho
Chang Young-Cheol
Cho Hoon
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Abstract
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In the present study, we synthesized 65 dichlorobenzylamine derivatives and investigated their algicidal activity against harmful red tides. The 3,4-dichlorobenzylamine derivatives showed relatively high activity against Cochlodinium polykrikoides, Heterosigma akashiwo, Chattonella marina, and Heterocapsa circularisquama, and the synthesized compounds 27, 28, 33, 34, 35, and 36 showed the highest algicidal activity after 24 h at 0.1 ~ 1.0 μM LC50 against the four harmful algae species. To verify the safety of the compounds, acute ecotoxicology tests using the water flea (Daphnia magna) and zebrafish (Danio rerio) were conducted, and the tests confirmed that compounds 33 and 34 were not harmful because the target organisms showed high survival rates at 15 μM. The results indicate that compounds 33 and 34 are suitable substances for use in controlling harmful algae species.
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KEYWORD
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harmful algae blooms, algicides, red tide, dichlorobenzylamine, ecotoxicology
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